Amphetamine-induced Dopaminergic Toxicity: a Single Dose Animal Model of Parkinson’s Disease
نویسندگان
چکیده
of the Dissertation.....................................................................ii Acknowledgments.........................................................................................................iv List of Figures................................................................................................................x Introduction....................................................................................................................1 Part I: Biomarkers and Models of Parkinson’s disease..................................................3 Parkinson’s disease.............................................................................................3 Amphetamine model of Parkinson’s disease....................................................12 Experiment 1: Acute effects of amphetamine.....................................15 Experiment 2: Long-term effects of amphetamine.............................22 Experiment 3: Effects of amphetamine in C57 mouse strain..............29 Experiment 4: Liver malondialdehyde................................................34 Experiment 5: Brain malondialdehyde................................................38 Discussion: Experiments 1 – 5..........................................................................42 Antioxidant defenses.........................................................................................44 Experiment 6: Ascorbic acid...............................................................49 Experiment 7: Trolox...........................................................................60 Experiment 8: Ibuprofen......................................................................68 Experiment 9: EGCG and Caffeine......................................................76 Discussion: Experiments 6 – 9...........................................................................92 Part II. The Behavioral Characterization and Amphetamine Toxicity in Genetic Knockouts as Potential Models of Parkinson’s disease..................................................95
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